Well we just did our first progesterone shot. Let me tell you, I haven't been looking forward to these. The syringes are so much bigger and longer, but my husband is a rock star! He did so good! My advice would be to ice the area for 15 minutes beforehand. I barely felt the needle go in and only felt when he pulled back on the syringe to check for blood. You have to do this step to make sure you haven't hit a vein, but are actually in the muscle. Check out this video to see a more in depth explanation. I watched it last night in preparation for tonight's event. At one point I even asked Kyle, "are you pushing in the medicine?" So it was a complete success! Thank goodness because we've got alot of these shots ahead of us! And when we get our positive (did you like how I said when? positive thinking here people!) I'm hoping that we will be moved to the suppositories instead of the shots.